1m93: Difference between revisions

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-[[Image:1m93.png|left|200px]]
-{{STRUCTURE_1m93|  PDB=1m93  |  SCENE=  }}
+==1.65 A Structure of Cleaved Viral Serpin CRMA==
+<StructureSection load='1m93' size='340' side='right'caption='[[1m93]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-===1.65 A Structure of Cleaved Viral Serpin CRMA===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1m93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M93 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10975564}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m93 OCA], [https://pdbe.org/1m93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m93 RCSB], [https://www.ebi.ac.uk/pdbsum/1m93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m93 ProSAT]</span></td></tr>
-[[1m93]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M93 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPI2_CWPXB SPI2_CWPXB] Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a "cross-class" interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B.<ref>PMID:1339309</ref> <ref>PMID:8034697</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m9/1m93_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m93 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Serpin|Serpin]]
+*[[Serpin 3D structures|Serpin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:010975564</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Cowpox virus]]
-[[Category: Gettins, P G.W.]]
+[[Category: Large Structures]]
-[[Category: Simonovic, M.]]
+[[Category: Gettins PGW]]
-[[Category: Volz, K.]]
+[[Category: Simonovic M]]
-[[Category: Apoptosis]]
+[[Category: Volz K]]
-[[Category: Crma]]
-[[Category: Ice inhibitor]]
-[[Category: Serpin]]
-[[Category: Viral protein]]