1u6h: Difference between revisions

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[[Image:1u6h.png|left|200px]]


{{STRUCTURE_1u6h|  PDB=1u6h  |  SCENE=  }}
==Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)==
 
<StructureSection load='1u6h' size='340' side='right'caption='[[1u6h]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
===Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1u6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U6H FirstGlance]. <br>
{{ABSTRACT_PUBMED_15642262}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6h OCA], [https://pdbe.org/1u6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u6h RCSB], [https://www.ebi.ac.uk/pdbsum/1u6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u6h ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1u6h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6H OCA].  
== Function ==
[https://www.uniprot.org/uniprot/VINC_CHICK VINC_CHICK] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:15229287</ref> <ref>PMID:20584916</ref> <ref>PMID:20086044</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u6/1u6h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u6h ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Talin|Talin]]
*[[Talin 3D structures|Talin 3D structures]]
*[[Vinculin|Vinculin]]
*[[Vinculin 3D structures|Vinculin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015642262</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Barsukov, I L.]]
[[Category: Large Structures]]
[[Category: Critchley, D R.]]
[[Category: Barsukov IL]]
[[Category: Emsley, J.]]
[[Category: Critchley DR]]
[[Category: Fillingham, I.]]
[[Category: Emsley J]]
[[Category: Gingras, A R.]]
[[Category: Fillingham I]]
[[Category: Papagrigoriou, E.]]
[[Category: Gingras AR]]
[[Category: Patel, B.]]
[[Category: Papagrigoriou E]]
[[Category: Roberts, G C.K.]]
[[Category: Patel B]]
[[Category: Cell adhesion]]
[[Category: Roberts GCK]]
[[Category: Protein-protein complex]]

Latest revision as of 09:16, 3 April 2024

Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)

Structural highlights

1u6h is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.38Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VINC_CHICK Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zhang Z, Izaguirre G, Lin SY, Lee HY, Schaefer E, Haimovich B. The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading. Mol Biol Cell. 2004 Sep;15(9):4234-47. Epub 2004 Jun 30. PMID:15229287 doi:10.1091/mbc.E04-03-0264
  2. ↑ le Duc Q, Shi Q, Blonk I, Sonnenberg A, Wang N, Leckband D, de Rooij J. Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol. 2010 Jun 28;189(7):1107-15. doi: 10.1083/jcb.201001149. PMID:20584916 doi:10.1083/jcb.201001149
  3. ↑ Peng X, Cuff LE, Lawton CD, DeMali KA. Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci. 2010 Feb 15;123(Pt 4):567-77. doi: 10.1242/jcs.056432. Epub 2010 Jan , 19. PMID:20086044 doi:10.1242/jcs.056432

1u6h, resolution 2.38Å

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