3ia4: Difference between revisions

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-[[Image:3ia4.png|left|200px]]
-{{STRUCTURE_3ia4|  PDB=3ia4  |  SCENE=  }}
+==Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)==
+<StructureSection load='3ia4' size='340' side='right'caption='[[3ia4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-===Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ia4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IA4 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19681091}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ia4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ia4 OCA], [https://pdbe.org/3ia4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ia4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ia4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ia4 ProSAT]</span></td></tr>
-[[3ia4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA4 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ia4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ia4 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Dihydrofolate reductase|Dihydrofolate reductase]]
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:019681091</ref><references group="xtra"/>
+[[Category: Large Structures]]
-[[Category: Dihydrofolate reductase]]
 [[Category: Moritella profunda]]
-[[Category: Levy, C.]]
+[[Category: Levy C]]
-[[Category: Dhfr dihydrofolate reductase]]
-[[Category: Methotrexate]]
-[[Category: Nadph]]
-[[Category: Oxidoreductase]]