1ve6: Difference between revisions

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-[[Image:1ve6.png|left|200px]]
-{{STRUCTURE_1ve6|  PDB=1ve6  |  SCENE=  }}
+==Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1==
+<StructureSection load='1ve6' size='340' side='right'caption='[[1ve6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ve6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VE6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ve6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ve6 OCA], [https://pdbe.org/1ve6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ve6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ve6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ve6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/APEH_AERPE APEH_AERPE] This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/1ve6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ve6 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Acylpeptide hydrolases (APH; also known as acylamino acid releasing enzyme) catalyze the removal of an N-acylated amino acid from blocked peptides. The crystal structure of an APH from the thermophilic archaeon Aeropyrum pernix K1 to 2.1 A resolution confirms it to be a member of the prolyl oligopeptidase family of serine proteases. The structure of apAPH is a symmetric homodimer with each subunit comprised of two domains. The N-terminal domain is a regular seven-bladed beta-propeller, while the C-terminal domain has a canonical alpha/beta hydrolase fold and includes the active site and a conserved Ser445-Asp524-His556 catalytic triad. The complex structure of apAPH with an organophosphorus substrate, p-nitrophenyl phosphate, has also been determined. The complex structure unambiguously maps out the substrate binding pocket and provides a basis for substrate recognition by apAPH. A conserved mechanism for protein degradation from archaea to mammals is suggested by the structural features of apAPH.
-===Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1===
+Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1.,Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z Structure. 2004 Aug;12(8):1481-8. PMID:15296741<ref>PMID:15296741</ref>
-{{ABSTRACT_PUBMED_15296741}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1ve6" style="background-color:#fffaf0;"></div>
-[[1ve6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VE6 OCA].
 ==See Also==
-*[[Acylaminoacyl peptidase|Acylaminoacyl peptidase]]
+*[[Acylaminoacyl peptidase 3D structures|Acylaminoacyl peptidase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015296741</ref><references group="xtra"/>
+__TOC__
-[[Category: Acylaminoacyl-peptidase]]
+</StructureSection>
 [[Category: Aeropyrum pernix]]
-[[Category: Bartlam, M.]]
+[[Category: Large Structures]]
-[[Category: Cao, S.]]
+[[Category: Bartlam M]]
-[[Category: Feng, Y.]]
+[[Category: Cao S]]
-[[Category: Gao, R.]]
+[[Category: Feng Y]]
-[[Category: Rao, Z.]]
+[[Category: Gao R]]
-[[Category: Wang, G.]]
+[[Category: Rao Z]]
-[[Category: Xie, G.]]
+[[Category: Wang G]]
-[[Category: Yang, H.]]
+[[Category: Xie G]]
-[[Category: Zhao, X.]]
+[[Category: Yang H]]
-[[Category: Alpha/beta hydrolase domain]]
+[[Category: Zhao X]]
-[[Category: Beta propeller domain]]
-[[Category: Hydrolase]]