4lzm: Difference between revisions

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-[[Image:4lzm.png|left|200px]]
-{{STRUCTURE_4lzm|  PDB=4lzm  |  SCENE=  }}
+==COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS==
+<StructureSection load='4lzm' size='340' side='right'caption='[[4lzm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-===COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4lzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LZM FirstGlance]. <br>
-{{ABSTRACT_PUBMED_2062826}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lzm OCA], [https://pdbe.org/4lzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lzm RCSB], [https://www.ebi.ac.uk/pdbsum/4lzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lzm ProSAT]</span></td></tr>
-[[4lzm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZM OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/4lzm_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4lzm ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
+*[[Lysozyme 3D structures|Lysozyme 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:002062826</ref><references group="xtra"/>
+__TOC__
-[[Category: Enterobacteria phage t4]]
+</StructureSection>
-[[Category: Lysozyme]]
+[[Category: Escherichia virus T4]]
-[[Category: Bell, J A.]]
+[[Category: Large Structures]]
-[[Category: Faber, H R.]]
+[[Category: Bell JA]]
-[[Category: Matthews, B W.]]
+[[Category: Faber HR]]
-[[Category: Nicholson, H.]]
+[[Category: Matthews BW]]
-[[Category: Wilson, K.]]
+[[Category: Nicholson H]]
-[[Category: Zhang, X J.]]
+[[Category: Wilson K]]
+[[Category: Zhang X-J]]