1cu0: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1cu0.png|left|200px]]
-{{STRUCTURE_1cu0|  PDB=1cu0  |  SCENE=  }}
+==T4 LYSOZYME MUTANT I78M==
+<StructureSection load='1cu0' size='340' side='right'caption='[[1cu0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-===T4 LYSOZYME MUTANT I78M===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1cu0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CU0 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10545167}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cu0 OCA], [https://pdbe.org/1cu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cu0 RCSB], [https://www.ebi.ac.uk/pdbsum/1cu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cu0 ProSAT]</span></td></tr>
-[[1cu0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CU0 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/1cu0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cu0 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
+*[[Lysozyme 3D structures|Lysozyme 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:010545167</ref><references group="xtra"/>
+__TOC__
-[[Category: Enterobacteria phage t4]]
+</StructureSection>
-[[Category: Lysozyme]]
+[[Category: Escherichia virus T4]]
-[[Category: Baase, W A.]]
+[[Category: Large Structures]]
-[[Category: Gassner, N C.]]
+[[Category: Baase WA]]
-[[Category: Lindstrom, J D.]]
+[[Category: Gassner NC]]
-[[Category: Lu, J.]]
+[[Category: Lindstrom JD]]
-[[Category: Matthews, B W.]]
+[[Category: Lu J]]
-[[Category: Hydrolase]]
+[[Category: Matthews BW]]
-[[Category: Methionine core mutant]]
-[[Category: Protein engineering]]
-[[Category: Protein folding]]
-[[Category: T4 lysozyme]]