31bi: Difference between revisions

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-[[Image:31bi.png|left|200px]]
-{{STRUCTURE_31bi|  PDB=31bi  |  SCENE=  }}
+==INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 71 REPLACED BY SER) (C71S)==
+<StructureSection load='31bi' size='340' side='right'caption='[[31bi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 71 REPLACED BY SER) (C71S)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[31bi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=31BI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=31BI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=31bi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=31bi OCA], [https://pdbe.org/31bi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=31bi RCSB], [https://www.ebi.ac.uk/pdbsum/31bi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=31bi ProSAT]</span></td></tr>
-[[31bi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=31BI OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/1b/31bi_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=31bi ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Interleukin|Interleukin]]
+*[[Interleukin 3D structures|Interleukin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Gilliland, G L.]]
+[[Category: Large Structures]]
-[[Category: Hirai, Y.]]
+[[Category: Gilliland GL]]
-[[Category: Masui, Y.]]
+[[Category: Hirai Y]]
-[[Category: Poulos, T L.]]
+[[Category: Masui Y]]
-[[Category: Veerapandian, B.]]
+[[Category: Poulos TL]]
-[[Category: Cytokine]]
+[[Category: Veerapandian B]]