2bvr: Difference between revisions
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==Human thrombin complexed with fragment-based small molecules occupying the S1 pocket== | |||
<StructureSection load='2bvr' size='340' side='right'caption='[[2bvr]], [[Resolution|resolution]] 1.25Å' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bvr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BVR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4CP:2-[2-(4-CHLORO-PHENYLSULFANYL)-ACETYLAMINO]-3-(4-GUANIDINO-PHENYL)-PROPIONAMIDE'>4CP</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr> | ||
[[2bvr]] is a 3 chain structure with sequence from [ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bvr OCA], [https://pdbe.org/2bvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bvr RCSB], [https://www.ebi.ac.uk/pdbsum/2bvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bvr ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HIRV2_HIRME HIRV2_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/2bvr_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bvr ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Hirudin|Hirudin]] | *[[Hirudin 3D structures|Hirudin 3D structures]] | ||
*[[Thrombin|Thrombin]] | *[[Thrombin 3D Structures|Thrombin 3D Structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hirudo medicinalis]] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Burkert | [[Category: Burkert K]] | ||
[[Category: Deppe | [[Category: Deppe H]] | ||
[[Category: Feurer | [[Category: Feurer A]] | ||
[[Category: Gamer | [[Category: Gamer J]] | ||
[[Category: Junker | [[Category: Junker H-D]] | ||
[[Category: Keil | [[Category: Keil O]] | ||
[[Category: Metz | [[Category: Metz G]] | ||
[[Category: Neumann | [[Category: Neumann T]] | ||
[[Category: Ottleben | [[Category: Ottleben H]] | ||
[[Category: Sekul | [[Category: Sekul R]] | ||
[[Category: Tomandl | [[Category: Tomandl D]] | ||
Latest revision as of 14:24, 22 May 2024
Human thrombin complexed with fragment-based small molecules occupying the S1 pocketHuman thrombin complexed with fragment-based small molecules occupying the S1 pocket
Structural highlights
FunctionHIRV2_HIRME Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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