1mr6: Difference between revisions

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-[[Image:1mr6.png|left|200px]]
-{{STRUCTURE_1mr6|  PDB=1mr6  |  SCENE=  }}
+==Solution Structure of gamma-Bungarotoxin:Implication for the role of the Residues Adjacent to RGD in Integrin Binding==
+<StructureSection load='1mr6' size='340' side='right'caption='[[1mr6]]' scene=''>
-===Solution Structure of gamma-Bungarotoxin:Implication for the role of the Residues Adjacent to RGD in Integrin Binding===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1mr6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MR6 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_15390258}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr6 OCA], [https://pdbe.org/1mr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mr6 RCSB], [https://www.ebi.ac.uk/pdbsum/1mr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mr6 ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1mr6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR6 OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/3NO5I_BUNMU 3NO5I_BUNMU] Exhibits M2 muscarinic acetylcholine receptor (CHRM2)-blocking activity, but has a weak binding activity toward nicotinic AChR. Moreover, it inhibits collagen-induced platelet aggregation.<ref>PMID:12168693</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mr6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mr6 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Bungarotoxin|Bungarotoxin]]
+*[[Bungarotoxin 3D structures|Bungarotoxin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015390258</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Bungarus multicinctus]]
-[[Category: Chang, L S.]]
+[[Category: Large Structures]]
-[[Category: Chen, C Y.]]
+[[Category: Chang L-S]]
-[[Category: Chen, Y C.]]
+[[Category: Chen C-Y]]
-[[Category: Chuang, W J.]]
+[[Category: Chen Y-C]]
-[[Category: Shiu, J H.]]
+[[Category: Chuang W-J]]
-[[Category: Neurotoxin]]
+[[Category: Shiu J-H]]
-[[Category: Toxin]]
-[[Category: Venom]]