1xvp: Difference between revisions

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-[[Image:1xvp.png|left|200px]]
-{{STRUCTURE_1xvp|  PDB=1xvp  |  SCENE=  }}
+==crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO==
+<StructureSection load='1xvp' size='340' side='right'caption='[[1xvp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-===crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1xvp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XVP FirstGlance]. <br>
-{{ABSTRACT_PUBMED_15610735}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CID:6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE+O-(3,4-DICHLOROBENZYL)OXIME'>CID</scene>, <scene name='pdbligand=F15:PENTADECANOIC+ACID'>F15</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xvp OCA], [https://pdbe.org/1xvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xvp RCSB], [https://www.ebi.ac.uk/pdbsum/1xvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xvp ProSAT]</span></td></tr>
-[[1xvp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XVP OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xvp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xvp ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Retinoid X receptor|Retinoid X receptor]]
+*[[Retinoid X receptor 3D structures|Retinoid X receptor 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015610735</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Lambert, M H.]]
+[[Category: Large Structures]]
-[[Category: Moore, J T.]]
+[[Category: Lambert MH]]
-[[Category: Moore, L B.]]
+[[Category: Moore JT]]
-[[Category: Waitt, G M.]]
+[[Category: Moore LB]]
-[[Category: Warren, E N.]]
+[[Category: Waitt GM]]
-[[Category: Weinert, E E.]]
+[[Category: Warren EN]]
-[[Category: Williams, J D.]]
+[[Category: Weinert EE]]
-[[Category: Willson, T M.]]
+[[Category: Williams JD]]
-[[Category: Wisely, B B.]]
+[[Category: Willson TM]]
-[[Category: Xu, R X.]]
+[[Category: Wisely BB]]
-[[Category: Car]]
+[[Category: Xu RX]]
-[[Category: Citco]]
-[[Category: Dna binding protein]]
-[[Category: Rxr]]
-[[Category: Src1]]