3o62: Difference between revisions

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-[[Image:3o62.png|left|200px]]
-{{STRUCTURE_3o62|  PDB=3o62  |  SCENE=  }}
+==Nucleosome core particle modified with a cisplatin 1,3-cis-{Pt(NH3)2}2+-d(GpTpG) intrastrand cross-link==
+<StructureSection load='3o62' size='340' side='right'caption='[[3o62]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
-===Nucleosome core particle modified with a cisplatin 1,3-cis-{Pt(NH3)2}2+-d(GpTpG) intrastrand cross-link===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3o62]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O62 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_21168769}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.216&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o62 OCA], [https://pdbe.org/3o62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o62 RCSB], [https://www.ebi.ac.uk/pdbsum/3o62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o62 ProSAT]</span></td></tr>
-[[3o62]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O62 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 ==See Also==
-*[[Histone|Histone]]
+*[[Histone 3D structures|Histone 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:021168769</ref><references group="xtra"/>
+[[Category: Large Structures]]
 [[Category: Xenopus laevis]]
-[[Category: Lippard, S J.]]
+[[Category: Lippard SJ]]
-[[Category: Todd, R C.]]
+[[Category: Todd RC]]
-[[Category: Cisplatin]]
-[[Category: Nucleosome]]
-[[Category: Structural protein-dna complex]]