2ovc: Difference between revisions

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-[[Image:2ovc.png|left|200px]]
-{{STRUCTURE_2ovc|  PDB=2ovc  |  SCENE=  }}
+==Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels==
+<StructureSection load='2ovc' size='340' side='right'caption='[[2ovc]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
-===Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ovc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OVC FirstGlance]. <br>
-{{ABSTRACT_PUBMED_17329207}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ovc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovc OCA], [https://pdbe.org/2ovc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ovc RCSB], [https://www.ebi.ac.uk/pdbsum/2ovc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovc ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[2ovc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVC OCA].
+== Disease ==
+[https://www.uniprot.org/uniprot/KCNQ4_HUMAN KCNQ4_HUMAN] Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A) [MIM:[https://omim.org/entry/600101 600101]. DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:10025409</ref> <ref>PMID:10369879</ref> <ref>PMID:10571947</ref> <ref>PMID:10925378</ref> <ref>PMID:21242547</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/KCNQ4_HUMAN KCNQ4_HUMAN] Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.<ref>PMID:11245603</ref>
 ==See Also==
-*[[Potassium Channel|Potassium Channel]]
+*[[Potassium channel 3D structures|Potassium channel 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:017329207</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Clark, K A.]]
+[[Category: Large Structures]]
-[[Category: Holton, J M.]]
+[[Category: Clark KA]]
-[[Category: Howard, R J.]]
+[[Category: Holton JM]]
-[[Category: Minor, D L.]]
+[[Category: Howard RJ]]
-[[Category: Coiled-coil]]
+[[Category: Minor DL]]
-[[Category: Ion channel assembly]]
-[[Category: Potassium channel]]
-[[Category: Tetramer]]
-[[Category: Transport protein]]
-[[Category: Voltage-gated channel]]