2y6d: Difference between revisions
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==The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger== | |||
<StructureSection load='2y6d' size='340' side='right'caption='[[2y6d]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2y6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQJ:N-[(2S)-1-[4-(5-BROMOPYRIDIN-2-YL)PIPERAZIN-1-YL]SULFONYL-5-PYRIMIDIN-2-YL-PENTAN-2-YL]-N-HYDROXY-METHANAMIDE'>TQJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[2y6d]] is a 1 chain structure with sequence from [ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6d OCA], [https://pdbe.org/2y6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6d RCSB], [https://www.ebi.ac.uk/pdbsum/2y6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6d ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MMP7_HUMAN MMP7_HUMAN] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<ref>PMID:2550050</ref> | |||
==See Also== | ==See Also== | ||
*[[Matrix metalloproteinase|Matrix metalloproteinase]] | *[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Edman | [[Category: Edman K]] | ||
[[Category: Furber | [[Category: Furber M]] | ||
[[Category: Hemsley | [[Category: Hemsley P]] | ||
[[Category: Johansson | [[Category: Johansson C]] | ||
[[Category: Pairaudeau | [[Category: Pairaudeau G]] | ||
[[Category: Petersen | [[Category: Petersen J]] | ||
[[Category: Stocks | [[Category: Stocks M]] | ||
[[Category: Tervo | [[Category: Tervo A]] | ||
[[Category: Ward | [[Category: Ward A]] | ||
[[Category: Wells | [[Category: Wells E]] | ||
[[Category: Wissler | [[Category: Wissler L]] | ||
Latest revision as of 17:02, 1 February 2024
The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity TriggerThe Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger
Structural highlights
FunctionMMP7_HUMAN Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.[1] See AlsoReferences |
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