2zv6: Difference between revisions

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-[[Image:2zv6.png|left|200px]]
-{{STRUCTURE_2zv6|  PDB=2zv6  |  SCENE=  }}
+==Crystal structure of human squamous cell carcinoma antigen 1==
+<StructureSection load='2zv6' size='340' side='right'caption='[[2zv6]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2zv6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZV6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv6 OCA], [https://pdbe.org/2zv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zv6 RCSB], [https://www.ebi.ac.uk/pdbsum/2zv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zv6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN] May act as a protease inhibitor to modulate the host immune response against tumor cells.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zv6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zv6 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Squamous cell carcinoma antigen 1 (SCCA1), which belongs to serine proteinase inhibitor (serpin) superfamily, inhibits papain-like cysteine proteinase. Recently, it has been reported that SCCA1 acts not only as a proteinase inhibitor but also as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). The present study determined the crystal structure of SCCA1, suggesting that the reactive center loop (RCL) of SCCA1, a recognition site of proteinase, is very flexible and located away form the main-body of SCCA1. We show that the inhibitory effect of SCCA1 on the kinase activity of JNK1 is lost when the RCL was truncated. Furthermore, we found that a mutant protein created by replacing one amino acid in RCL maintain the suppressive activity to JNK1, whereas the inhibitory effect to proteinase is obviously decreased.
-===Crystal structure of human squamous cell carcinoma antigen 1===
+Crystal structure of SCCA1 and insight about the interaction with JNK1.,Zheng B, Matoba Y, Kumagai T, Katagiri C, Hibino T, Sugiyama M Biochem Biophys Res Commun. 2009 Feb 27;380(1):143-7. Epub 2009 Jan 21. PMID:19166818<ref>PMID:19166818</ref>
-{{ABSTRACT_PUBMED_19166818}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2zv6" style="background-color:#fffaf0;"></div>
-[[2zv6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV6 OCA].
 ==See Also==
-*[[Serpin|Serpin]]
+*[[Serpin 3D structures|Serpin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019166818</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Hibino, T.]]
+[[Category: Large Structures]]
-[[Category: Katagiri, C.]]
+[[Category: Hibino T]]
-[[Category: Matoba, Y.]]
+[[Category: Katagiri C]]
-[[Category: Sugiyama, M.]]
+[[Category: Matoba Y]]
-[[Category: Zheng, B.]]
+[[Category: Sugiyama M]]
-[[Category: Hydrolase inhibitor]]
+[[Category: Zheng B]]
-[[Category: Protease inhibitor]]
-[[Category: Reactive site loop]]
-[[Category: Serine protease inhibitor]]
-[[Category: Serine proteinase inhibitor]]