2l1m: Difference between revisions

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-[[Image:2l1m.png|left|200px]]
-{{STRUCTURE_2l1m|  PDB=2l1m  |  SCENE=  }}
+==Solution structure of the eag domain of the hERG (Kv11.1) K+ channel==
+<StructureSection load='2l1m' size='340' side='right'caption='[[2l1m]]' scene=''>
-===Solution structure of the eag domain of the hERG (Kv11.1) K+ channel===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2l1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1M FirstGlance]. <br>
-{{ABSTRACT_PUBMED_21135103}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1m OCA], [https://pdbe.org/2l1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1m RCSB], [https://www.ebi.ac.uk/pdbsum/2l1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1m ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[2l1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1M OCA].
+== Disease ==
+[https://www.uniprot.org/uniprot/KCNH2_HUMAN KCNH2_HUMAN] Defects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:[https://omim.org/entry/613688 613688]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2.<ref>PMID:16361248</ref> <ref>PMID:9600240</ref> <ref>PMID:7889573</ref> <ref>PMID:8914737</ref> <ref>PMID:8635257</ref> <ref>PMID:8877771</ref> <ref>PMID:9024139</ref> <ref>PMID:9693036</ref> <ref>PMID:9544837</ref> <ref>PMID:9452080</ref> <ref>PMID:10086971</ref> <ref>PMID:10220144</ref> <ref>PMID:10187793</ref> <ref>PMID:10517660</ref> <ref>PMID:10735633</ref> <ref>PMID:10973849</ref> <ref>PMID:10862094</ref> <ref>PMID:10753933</ref> <ref>PMID:12062363</ref> <ref>PMID:12354768</ref> <ref>PMID:12621127</ref> <ref>PMID:15051636</ref> <ref>PMID:15840476</ref> <ref>PMID:22314138</ref>   Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:[https://omim.org/entry/609620 609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.<ref>PMID:14676148</ref> <ref>PMID:15828882</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/KCNH2_HUMAN KCNH2_HUMAN] Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
 ==See Also==
-*[[Potassium Channel|Potassium Channel]]
+*[[Potassium channel 3D structures|Potassium channel 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021135103</ref><ref group="xtra">PMID:017132624</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Mitcheson, J S.]]
+[[Category: Large Structures]]
-[[Category: Muskett, F W.]]
+[[Category: Mitcheson JS]]
-[[Category: Eag domain]]
+[[Category: Muskett FW]]
-[[Category: Herg]]
-[[Category: Kv11 1]]
-[[Category: Pas domain]]
-[[Category: Transport protein]]