4hej: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 4hej is ON HOLD
+==Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK): Compund 16==
+<StructureSection load='4hej' size='340' side='right'caption='[[4hej]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4hej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HEJ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14D:5-METHYL-1-[(3S)-1-{3-[3-(TRIFLUOROMETHYL)PHENOXY]BENZYL}PIPERIDIN-3-YL]PYRIMIDINE-2,4(1H,3H)-DIONE'>14D</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hej OCA], [https://pdbe.org/4hej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hej RCSB], [https://www.ebi.ac.uk/pdbsum/4hej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hej ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KTHY_STAAN KTHY_STAAN] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.[HAMAP-Rule:MF_00165]
-Authors: Martinez-Botella, G., Breen, J., Duffy, J., Dumas, J., Geng, B., Gowers, I., Green, O., Guler, S., Hentemann, M., Hernandez-Juan, F., Joseph-McCarthy, D., Kawatkar, S., Larsen, N., Lazari, O., Loch, J., Macritchie, J.
+==See Also==
+*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
-Description: Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK): Compund 16
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Staphylococcus aureus subsp. aureus N315]]
+[[Category: Breen J]]
+[[Category: Duffy J]]
+[[Category: Dumas J]]
+[[Category: Geng B]]
+[[Category: Gowers I]]
+[[Category: Green O]]
+[[Category: Guler S]]
+[[Category: Hentemann M]]
+[[Category: Hernandez-Juan F]]
+[[Category: Joseph-McCarthy D]]
+[[Category: Kawatkar S]]
+[[Category: Larsen N]]
+[[Category: Lazari O]]
+[[Category: Loch J]]
+[[Category: Macritchie J]]
+[[Category: Martinez-Botella G]]