4gzc: Difference between revisions

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New page: '''Unreleased structure''' The entry 4gzc is ON HOLD Authors: Costakes, G.T., Stauffacher, C.V. Description: Crystal Structure of Yeast ENTH2
 
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'''Unreleased structure'''


The entry 4gzc is ON HOLD
==Crystal structure of yeast Ent2 ENTH domain==
<StructureSection load='4gzc' size='340' side='right'caption='[[4gzc]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzc OCA], [https://pdbe.org/4gzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzc RCSB], [https://www.ebi.ac.uk/pdbsum/4gzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENT2_YEAST ENT2_YEAST] Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin.<ref>PMID:10449404</ref>


Authors: Costakes, G.T., Stauffacher, C.V.
==See Also==
 
*[[Epsin|Epsin]]
Description: Crystal Structure of Yeast ENTH2
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Costakes GT]]
[[Category: Stauffacher CV]]

Latest revision as of 14:35, 1 March 2024

Crystal structure of yeast Ent2 ENTH domainCrystal structure of yeast Ent2 ENTH domain

Structural highlights

4gzc is a 1 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENT2_YEAST Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin.[1]

See Also

References

  1. ↑ Wendland B, Steece KE, Emr SD. Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J. 1999 Aug 16;18(16):4383-93. PMID:10449404 doi:10.1093/emboj/18.16.4383

4gzc, resolution 1.30Å

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