4b89: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4b89 is ON HOLD
+==MIF4G domain of the yeast Not1==
+<StructureSection load='4b89' size='340' side='right'caption='[[4b89]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Basquin, J., Conti, E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4b89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B89 FirstGlance]. <br>
-Description: MIF4G domain of the yeast Not1
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b89 OCA], [https://pdbe.org/4b89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b89 RCSB], [https://www.ebi.ac.uk/pdbsum/4b89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b89 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOT1_YEAST NOT1_YEAST] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.<ref>PMID:9463387</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Saccharomyces cerevisiae S288C]]
+[[Category: Basquin J]]
+[[Category: Conti E]]