3twm: Difference between revisions

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-[[Image:3twm.png|left|200px]]
-{{STRUCTURE_3twm|  PDB=3twm  |  SCENE=  }}
+==Crystal structure of Arabidopsis thaliana FPG==
+<StructureSection load='3twm' size='340' side='right'caption='[[3twm]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3twm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twm OCA], [https://pdbe.org/3twm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twm RCSB], [https://www.ebi.ac.uk/pdbsum/3twm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FPG_ARATH FPG_ARATH] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Can process efficiently 4,6-diamino-5-formamidopyrimidine (FapyA), 2,6-diamino-4- hydroxy-5-formamidopyrimidine (FapyG) and the further oxidation products of 8-oxoguanine (8-oxoG), such as guanidinohydantoin and spiroiminodihydantoin. Has marginal activity towards 8-oxoG. Has AP (apurinic/apyrimidinic) lyase activity. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.<ref>PMID:11272725</ref> <ref>PMID:22789755</ref> <ref>PMID:9819050</ref>
-===Crystal structure of Arabidopsis thaliana FPG===
+==See Also==
+*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
-{{ABSTRACT_PUBMED_22789755}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3twm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWM OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:022789755</ref><references group="xtra"/>
 [[Category: Arabidopsis thaliana]]
-[[Category: DNA-formamidopyrimidine glycosylase]]
+[[Category: Large Structures]]
-[[Category: Aller, P.]]
+[[Category: Aller P]]
-[[Category: Doublie, S.]]
+[[Category: Doublie S]]
-[[Category: Duclos, S.]]
+[[Category: Duclos S]]
-[[Category: Wallace, S S.]]
+[[Category: Wallace SS]]
-[[Category: Dna containing stable analog of abasic site]]
-[[Category: Dna damage]]
-[[Category: Dna repair]]
-[[Category: Dna-binding]]
-[[Category: Glycosidase]]
-[[Category: Helix two turns helix]]
-[[Category: Hydrolase]]
-[[Category: Hydrolase-dna complex]]
-[[Category: Lyase]]
-[[Category: Multifunctional enzyme]]
-[[Category: Tetrahydro furan]]
-[[Category: Zinc-less finger]]