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[[Image:4frf.jpg|left|200px]]


{{STRUCTURE_4frf|  PDB=4frf  |  SCENE=  }}
==Structural Studies and Protein Engineering of Inositol Phosphate Multikinase==
 
<StructureSection load='4frf' size='340' side='right'caption='[[4frf]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
===Structural Studies and Protein Engineering of Inositol Phosphate Multikinase===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4frf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FRF FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[4frf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FRF OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4frf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4frf OCA], [https://pdbe.org/4frf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4frf RCSB], [https://www.ebi.ac.uk/pdbsum/4frf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4frf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IPMKA_ARATH IPMKA_ARATH] Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) and inositol 1,2,3,4,6-pentakisphosphate (Ins(1,2,3,4,6)P5) but not inositol 1,4-bisphosphate (Ins(1,4)P2), inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), inositol 1,2,6-trisphosphate (Ins(1,2,6)P3), inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P4), inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5), inositol 1,2,4,5,6-pentakisphosphate (Ins(1,2,4,5,6)P5) or inositol hexakisphosphate (InsP6). Regulates pollen and root development probably through the regulation of InsP3-mediated calcium accumulation.<ref>PMID:12226109</ref> <ref>PMID:15618435</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Endo-Streeter, S T.]]
[[Category: Large Structures]]
[[Category: Odom, A R.]]
[[Category: Endo-Streeter ST]]
[[Category: Tsui, M.]]
[[Category: Odom AR]]
[[Category: York, J D.]]
[[Category: Tsui M]]
[[Category: Atp grasp]]
[[Category: York JD]]
[[Category: Inositol phosphate kinase]]
[[Category: Transferase]]

Latest revision as of 14:23, 1 March 2024

Structural Studies and Protein Engineering of Inositol Phosphate MultikinaseStructural Studies and Protein Engineering of Inositol Phosphate Multikinase

Structural highlights

4frf is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IPMKA_ARATH Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) and inositol 1,2,3,4,6-pentakisphosphate (Ins(1,2,3,4,6)P5) but not inositol 1,4-bisphosphate (Ins(1,4)P2), inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), inositol 1,2,6-trisphosphate (Ins(1,2,6)P3), inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P4), inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5), inositol 1,2,4,5,6-pentakisphosphate (Ins(1,2,4,5,6)P5) or inositol hexakisphosphate (InsP6). Regulates pollen and root development probably through the regulation of InsP3-mediated calcium accumulation.[1] [2]

References

  1. ↑ Stevenson-Paulik J, Odom AR, York JD. Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. J Biol Chem. 2002 Nov 8;277(45):42711-8. Epub 2002 Sep 10. PMID:12226109 doi:http://dx.doi.org/10.1074/jbc.M209112200
  2. ↑ Xu J, Brearley CA, Lin WH, Wang Y, Ye R, Mueller-Roeber B, Xu ZH, Xue HW. A role of Arabidopsis inositol polyphosphate kinase, AtIPK2alpha, in pollen germination and root growth. Plant Physiol. 2005 Jan;137(1):94-103. Epub 2004 Dec 23. PMID:15618435 doi:http://dx.doi.org/pp.104.045427

4frf, resolution 2.90Å

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