4b4y: Difference between revisions
New page: '''Unreleased structure''' The entry 4b4y is ON HOLD Authors: Lechauve, C., Jager, M., Laguerre, L., Kiger, L., Correc, G., Leroux, C., Vinogradov, S., Czjzek, M., Marden, M.C., Bailly,... |
No edit summary |
||
| (9 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==crystal structure of the neuroglobin from the photosymbiotic marine acoel Symsagittifera roscoffensis== | |||
<StructureSection load='4b4y' size='340' side='right'caption='[[4b4y]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4b4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Symsagittifera_roscoffensis Symsagittifera roscoffensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B4Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4y OCA], [https://pdbe.org/4b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b4y RCSB], [https://www.ebi.ac.uk/pdbsum/4b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b4y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/L7MTK4_SYMRO L7MTK4_SYMRO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Neuroglobins, previously thought to be restricted to vertebrate neurons, were detected in the brain of a photosymbiotic acoel, Symsagittifera roscoffensis, and in neuro-sensory cells of the jellyfish Clytia hemisphaerica. For the neuroglobin of S. roscoffensis, a member of a lineage that originated either at the base of the bilateria or of the deuterostome clade, we report the ligand-binding properties, crystal structure at 2.3 A and brain immuno-cytochemical pattern. We also describe in situ hybridizations of two neuroglobins specifically expressed in differentiating nematocytes (neuro-sensory cells) and in statocytes (ciliated mechano-sensory cells) of C. hemisphaerica, a member of the early-branching animal phylum cnidaria. In silico searches using these neuroglobins as queries revealed the presence of previously unidentified neuroglobin-like sequences in most metazoan lineages. Since neural systems are almost ubiquitous in metazoa, the constitutive expression of neuroglobin-like proteins strongly supports the notion of an intimate association of neuroglobins with the evolution of animal neural systems and hints at the preservation of a vitally important function. Neuroglobins were probably recruited in the first proto-neurons in early metazoans from globin precursors. Neuroglobins were identified in choanoflagellates, sponges and placozoans, and were conserved during nervous system evolution. Since the origin of neuroglobins predates the other metazoan globins, it is likely that neuroglobin gene duplication followed by co-option and subfunctionalization led to the emergence of globin families in protostomes and deuterostomes (i.e convergent evolution). | |||
Neuroglobins: pivotal proteins associated with emerging neural systems and precursors of metazoan globin diversity.,Lechauve C, Jager M, Laguerre L, Kiger L, Correc G, Leroux C, Vinogradov S, Czjzek M, Marden MC, Bailly X J Biol Chem. 2013 Jan 3. PMID:23288852<ref>PMID:23288852</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4b4y" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Neuroglobin|Neuroglobin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Symsagittifera roscoffensis]] | |||
[[Category: Bailly X]] | |||
[[Category: Correc G]] | |||
[[Category: Czjzek M]] | |||
[[Category: Jager M]] | |||
[[Category: Kiger L]] | |||
[[Category: Laguerre L]] | |||
[[Category: Lechauve C]] | |||
[[Category: Leroux C]] | |||
[[Category: Marden MC]] | |||
[[Category: Vinogradov S]] | |||