2euf: Difference between revisions

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[[Image:2euf.png|left|200px]]


{{STRUCTURE_2euf|  PDB=2euf  |  SCENE=  }}
==X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991==
 
<StructureSection load='2euf' size='340' side='right'caption='[[2euf]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
===X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2euf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesvirus_saimiri_(strain_11) Herpesvirus saimiri (strain 11)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EUF FirstGlance]. <br>
{{ABSTRACT_PUBMED_16789739}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LQQ:6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE'>LQQ</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2euf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2euf OCA], [https://pdbe.org/2euf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2euf RCSB], [https://www.ebi.ac.uk/pdbsum/2euf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2euf ProSAT]</span></td></tr>
[[2euf]] is a 2 chain structure of [[Cyclin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUF OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CGH2_SHV21 CGH2_SHV21] May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/2euf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2euf ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cyclin|Cyclin]]
*[[Cyclin 3D structures|Cyclin 3D structures]]
 
*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
==Reference==
__TOC__
<ref group="xtra">PMID:016789739</ref><references group="xtra"/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Viruses]]
[[Category: Lu H]]
[[Category: Lu, H.]]
[[Category: Schulze-Gahmen U]]
[[Category: Schulze-Gahmen, U.]]
[[Category: Cell cycle-transferase complex]]
[[Category: Inhibitor complex of human cyclin-dependent kinase 6]]

Latest revision as of 12:19, 14 February 2024

X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991

Structural highlights

2euf is a 2 chain structure with sequence from Herpesvirus saimiri (strain 11) and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CGH2_SHV21 May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2euf, resolution 3.00Å

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