1fuo: Difference between revisions

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[[Image:1fuo.png|left|200px]]


{{STRUCTURE_1fuo|  PDB=1fuo  |  SCENE=  }}
==FUMARASE C WITH BOUND CITRATE==
 
<StructureSection load='1fuo' size='340' side='right'caption='[[1fuo]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
===FUMARASE C WITH BOUND CITRATE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1fuo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The October 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citric Acid Cycle''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_10 10.2210/rcsb_pdb/mom_2012_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FUO FirstGlance]. <br>
{{ABSTRACT_PUBMED_8909293}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fuo OCA], [https://pdbe.org/1fuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fuo RCSB], [https://www.ebi.ac.uk/pdbsum/1fuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fuo ProSAT]</span></td></tr>
[[1fuo]] is a 2 chain structure of [[Fumarase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUO OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/FUMC_ECOLI FUMC_ECOLI] Catalyzes the reversible addition of water to fumarate to give L-malate.<ref>PMID:1917897</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/1fuo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fuo ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Fumarase|Fumarase]]
*[[Fumarase|Fumarase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:008909293</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Citric Acid Cycle]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Fumarate hydratase]]
[[Category: Large Structures]]
[[Category: Banaszak, L.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Weaver, T.]]
[[Category: Banaszak L]]
[[Category: Lyase]]
[[Category: Weaver T]]
[[Category: Tricarboxylic acid cycle]]

Latest revision as of 10:19, 7 February 2024

FUMARASE C WITH BOUND CITRATEFUMARASE C WITH BOUND CITRATE

Structural highlights

1fuo is a 2 chain structure with sequence from Escherichia coli. The October 2012 RCSB PDB Molecule of the Month feature on Citric Acid Cycle by David Goodsell is 10.2210/rcsb_pdb/mom_2012_10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.98Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FUMC_ECOLI Catalyzes the reversible addition of water to fumarate to give L-malate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Ueda Y, Yumoto N, Tokushige M, Fukui K, Ohya-Nishiguchi H. Purification and characterization of two types of fumarase from Escherichia coli. J Biochem. 1991 May;109(5):728-33. PMID:1917897

1fuo, resolution 1.98Å

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