3v6h: Difference between revisions

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[[Image:3v6h.png|left|200px]]


{{STRUCTURE_3v6h|  PDB=3v6h  |  SCENE=  }}
==Replication of N2,3-Ethenoguanine by DNA Polymerases==
 
<StructureSection load='3v6h' size='340' side='right'caption='[[3v6h]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Replication of N2,3-Ethenoguanine by DNA Polymerases===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3v6h]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6H FirstGlance]. <br>
{{ABSTRACT_PUBMED_22488769}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DCP:2-DEOXYCYTIDINE-5-TRIPHOSPHATE'>DCP</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=EFG:1-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZO[2,1-B]PURIN-4(5H)-ONE'>EFG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6h OCA], [https://pdbe.org/3v6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6h RCSB], [https://www.ebi.ac.uk/pdbsum/3v6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6h ProSAT]</span></td></tr>
[[3v6h]] is a 6 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6H OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO4_SACS2 DPO4_SACS2] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.


==See Also==
==See Also==
*[[DNA polymerase|DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022488769</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: DNA-directed DNA polymerase]]
[[Category: Saccharolobus solfataricus P2]]
[[Category: Sulfolobus solfataricus p2]]
[[Category: Zhao L]]
[[Category: Zhao, L.]]
[[Category: 2'-fluoro arabinose]]
[[Category: 3-ethenoguanine]]
[[Category: Dna adduct]]
[[Category: Dna lesion]]
[[Category: Dna polymerase]]
[[Category: Dna replication]]
[[Category: Dpo4]]
[[Category: Ethenoguanine]]
[[Category: Lesion bypass]]
[[Category: N2]]
[[Category: Sulfolobus solfataricus dna polymerase iv]]
[[Category: Transferase-dna complex]]

Latest revision as of 17:19, 14 March 2024

Replication of N2,3-Ethenoguanine by DNA PolymerasesReplication of N2,3-Ethenoguanine by DNA Polymerases

Structural highlights

3v6h is a 6 chain structure with sequence from Saccharolobus solfataricus P2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPO4_SACS2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.

See Also

3v6h, resolution 2.30Å

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