1h8m: Difference between revisions

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-[[Image:1h8m.gif|left|200px]]<br /><applet load="1h8m" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1h8m" />
-'''SOLUTION STRUCTURE OF YKT6'''<br />
-==Overview==
+==Solution structure of ykt6==
+<StructureSection load='1h8m' size='340' side='right'caption='[[1h8m]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1h8m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H8M FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8m OCA], [https://pdbe.org/1h8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h8m RCSB], [https://www.ebi.ac.uk/pdbsum/1h8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8m ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/YKT6_YEAST YKT6_YEAST]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8m_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h8m ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps. Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted a folded back conformation in which Ykt6pN bound to its COOH-terminal core domain. The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes.
-==About this Structure==
+An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p.,Tochio H, Tsui MM, Banfield DK, Zhang M Science. 2001 Jul 27;293(5530):698-702. PMID:11474112<ref>PMID:11474112</ref>
-H8M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8M OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p., Tochio H, Tsui MM, Banfield DK, Zhang M, Science. 2001 Jul 27;293(5530):698-702. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11474112 11474112]
+</div>
+<div class="pdbe-citations 1h8m" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Single protein]]
+[[Category: Banfield DK]]
-[[Category: Banfield, D K.]]
+[[Category: Tochio H]]
-[[Category: Tochio, H.]]
+[[Category: Tsui MMK]]
-[[Category: Tsui, M M.K.]]
+[[Category: Zhang M]]
-[[Category: Zhang, M.]]
-[[Category: prenylation]]
-[[Category: transmembrane lipoprotein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:58:37 2008''