1dut: Difference between revisions

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[[Image:1dut.png|left|200px]]


{{STRUCTURE_1dut|  PDB=1dut  |  SCENE= }}
==FIV DUTP PYROPHOSPHATASE==
 
<StructureSection load='1dut' size='340' side='right'caption='[[1dut]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===FIV DUTP PYROPHOSPHATASE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1dut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Feline_immunodeficiency_virus_(isolate_Petaluma) Feline immunodeficiency virus (isolate Petaluma)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DUT FirstGlance]. <br>
{{ABSTRACT_PUBMED_8976551}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dut OCA], [https://pdbe.org/1dut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dut RCSB], [https://www.ebi.ac.uk/pdbsum/1dut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dut ProSAT]</span></td></tr>
[[1dut]] is a 2 chain structure of [[Deoxyuridine 5'-triphosphate nucleotidohydrolase]] with sequence from [http://en.wikipedia.org/wiki/Feline_immunodeficiency_virus Feline immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/POL_FIVPE POL_FIVPE] During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/1dut_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dut ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
*[[DUTPase 3D structures|DUTPase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:008976551</ref><ref group="xtra">PMID:009878436</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Feline immunodeficiency virus]]
[[Category: Elder JH]]
[[Category: DUTP diphosphatase]]
[[Category: Hasselkus-Light C]]
[[Category: Elder, J H.]]
[[Category: Laco GS]]
[[Category: Hasselkus-Light, C.]]
[[Category: Mcree DE]]
[[Category: Laco, G S.]]
[[Category: Prasad GS]]
[[Category: Mcree, D E.]]
[[Category: Stout CD]]
[[Category: Prasad, G S.]]
[[Category: Stura EA]]
[[Category: Stout, C D.]]
[[Category: Stura, E A.]]
[[Category: Acid anhydride hydrolase]]
[[Category: Aspartyl protease]]
[[Category: Endonuclease]]
[[Category: Hydrolase]]
[[Category: Nucleotide metabolism]]
[[Category: Polyprotein]]
[[Category: Rna-directed dna polymerase]]

Latest revision as of 09:59, 7 February 2024

FIV DUTP PYROPHOSPHATASEFIV DUTP PYROPHOSPHATASE

Structural highlights

1dut is a 2 chain structure with sequence from Feline immunodeficiency virus (isolate Petaluma). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

POL_FIVPE During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1dut, resolution 1.90Å

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