2bjo: Difference between revisions

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-[[Image:2bjo.png|left|200px]]
-{{STRUCTURE_2bjo|  PDB=2bjo  |  SCENE=  }}
+==Crystal Structure of the Organic Hydroperoxide Resistance Protein OhrB of Bacillus subtilis==
+<StructureSection load='2bjo' size='340' side='right'caption='[[2bjo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2bjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BJO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bjo OCA], [https://pdbe.org/2bjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bjo RCSB], [https://www.ebi.ac.uk/pdbsum/2bjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bjo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/OHRB_BACSU OHRB_BACSU] Involved in organic hydroperoxide resistance.<ref>PMID:11418552</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/2bjo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bjo ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structure of the fully oxidized form of the Bacillus subtilis organic hydroperoxide-resistance (OhrB) protein is reported at 2.1 A resolution. The electron density reveals an intact catalytic disulfide bond (Cys55-Cys119) in each of the two molecules, which are intertwined into a canonical obligate dimer. However, the stereochemistry of the disulfides is unorthodox and strained, suggesting that they are sensitive to reducing agents. A deep solvent-accessible gorge reaching Cys55 may represent the access route for the reductant.
-===CRYSTAL STRUCTURE OF THE ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN OHRB OF BACILLUS SUBTILIS===
+Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state.,Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1269-73. Epub 2007, Nov 16. PMID:18084074<ref>PMID:18084074</ref>
-{{ABSTRACT_PUBMED_18084074}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2bjo" style="background-color:#fffaf0;"></div>
-[[2bjo]] is a 2 chain structure of [[Organic hydroperoxide resistance protein]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJO OCA].
 ==See Also==
 *[[Organic hydroperoxide resistance protein|Organic hydroperoxide resistance protein]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018084074</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Bacillus subtilis]]
-[[Category: Bielnicki, J.]]
+[[Category: Large Structures]]
-[[Category: Cooper, D R.]]
+[[Category: Bielnicki J]]
-[[Category: Derewenda, Z S.]]
+[[Category: Cooper DR]]
-[[Category: Devedjiev, Y.]]
+[[Category: Derewenda ZS]]
-[[Category: Joachimiak, A.]]
+[[Category: Devedjiev Y]]
-[[Category: Surendranath, Y.]]
+[[Category: Joachimiak A]]
-[[Category: Heat shock protein]]
+[[Category: Surendranath Y]]
-[[Category: Organic hydroperoxide resistance]]
-[[Category: Oxidoreductase]]