3e6t: Difference between revisions

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[[Image:3e6t.png|left|200px]]


{{STRUCTURE_3e6t|  PDB=3e6t  |  SCENE=  }}
==Structure of murine INOS oxygenase domain with inhibitor AR-C118901==
 
<StructureSection load='3e6t' size='340' side='right'caption='[[3e6t]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Structure of murine INOS oxygenase domain with inhibitor AR-C118901===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3e6t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E6T FirstGlance]. <br>
{{ABSTRACT_PUBMED_18849972}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1A2:5-(4-AMINO-1-ETHYL-5,8-DIFLUORO-1H-SPIRO[PIPERIDINE-4,2-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE'>1A2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6t OCA], [https://pdbe.org/3e6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e6t RCSB], [https://www.ebi.ac.uk/pdbsum/3e6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e6t ProSAT]</span></td></tr>
[[3e6t]] is a 2 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6T OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e6t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e6t ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018849972</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Nitric-oxide synthase]]
[[Category: Aberg A]]
[[Category: Aberg, A.]]
[[Category: Andersson G]]
[[Category: Andersson, G.]]
[[Category: Andrews G]]
[[Category: Andrews, G.]]
[[Category: Arvai AS]]
[[Category: Arvai, A S.]]
[[Category: Cheshire DR]]
[[Category: Cheshire, D R.]]
[[Category: Connolly S]]
[[Category: Connolly, S.]]
[[Category: Crane BR]]
[[Category: Crane, B R.]]
[[Category: Garcin ED]]
[[Category: Garcin, E D.]]
[[Category: Gensmantel NP]]
[[Category: Gensmantel, N P.]]
[[Category: Getzoff ED]]
[[Category: Getzoff, E D.]]
[[Category: Hamley PJ]]
[[Category: Hamley, P J.]]
[[Category: Kroeger MD]]
[[Category: Kroeger, M D.]]
[[Category: Mallinder PR]]
[[Category: Mallinder, P R.]]
[[Category: Mete A]]
[[Category: Mete, A.]]
[[Category: Nicholls DJ]]
[[Category: Nicholls, D J.]]
[[Category: Rosenfeld RJ]]
[[Category: Rosenfeld, R J.]]
[[Category: St-Gallay SA]]
[[Category: St-Gallay, S A.]]
[[Category: Stueh DJ]]
[[Category: Stueh, D J.]]
[[Category: Tainer JA]]
[[Category: Tainer, J A.]]
[[Category: Tinker AC]]
[[Category: Tinker, A C.]]
[[Category: Wallace AV]]
[[Category: Wallace, A V.]]
[[Category: Calmodulin-binding]]
[[Category: Fad]]
[[Category: Fmn]]
[[Category: Heme]]
[[Category: Iron]]
[[Category: Metal-binding]]
[[Category: Nadp]]
[[Category: Nitric oxide]]
[[Category: No]]
[[Category: Oxidoreductase]]
[[Category: Tetrahydrobiopterin]]

Latest revision as of 12:45, 21 February 2024

Structure of murine INOS oxygenase domain with inhibitor AR-C118901Structure of murine INOS oxygenase domain with inhibitor AR-C118901

Structural highlights

3e6t is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NOS2_MOUSE Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005 Dec 23;310(5756):1966-70. PMID:16373578 doi:http://dx.doi.org/10.1126/science.1119407

3e6t, resolution 2.50Å

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