1c25: Difference between revisions

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-[[Image:1c25.png|left|200px]]
-{{STRUCTURE_1c25|  PDB=1c25  |  SCENE=  }}
+==HUMAN CDC25A CATALYTIC DOMAIN==
+<StructureSection load='1c25' size='340' side='right'caption='[[1c25]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-===HUMAN CDC25A CATALYTIC DOMAIN===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1c25]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C25 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_9604936}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c25 OCA], [https://pdbe.org/1c25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c25 RCSB], [https://www.ebi.ac.uk/pdbsum/1c25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c25 ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1c25]] is a 1 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C25 OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/MPIP1_HUMAN MPIP1_HUMAN] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/1c25_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c25 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:009604936</ref><ref group="xtra">PMID:014695246</ref><ref group="xtra">PMID:015937284</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Large Structures]]
-[[Category: Cogswell, J P.]]
+[[Category: Cogswell JP]]
-[[Category: Fauman, E B.]]
+[[Category: Fauman EB]]
-[[Category: Holmes, W.]]
+[[Category: Holmes W]]
-[[Category: Lovejoy, B.]]
+[[Category: Lovejoy B]]
-[[Category: Montana, V G.]]
+[[Category: Montana VG]]
-[[Category: Piwnica-Worms, H.]]
+[[Category: Piwnica-Worms H]]
-[[Category: Rink, M J.]]
+[[Category: Rink MJ]]
-[[Category: Rocque, W J.]]
+[[Category: Rocque WJ]]
-[[Category: Saper, M A.]]
+[[Category: Saper MA]]
-[[Category: Cdk2]]
-[[Category: Cell cycle phosphatase]]
-[[Category: Dual specificity protein phosphatase]]
-[[Category: Hydrolase]]