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[[Image:3tm0.png|left|200px]]


{{STRUCTURE_3tm0|  PDB=3tm0  |  SCENE=  }}
==Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Butirosin A Complex==
 
<StructureSection load='3tm0' size='340' side='right'caption='[[3tm0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Butirosin A Complex===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3tm0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3h8p 3h8p]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TM0 FirstGlance]. <br>
{{ABSTRACT_PUBMED_19433564}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=B31:(2S)-4-AMINO-N-[(1R,2S,3R,4R,5S)-5-AMINO-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXY-3-(BETA-D-XYLOFURANOSYLOXY)CYCLOHEXYL]-2-HYDROXYBUTANAMIDE'>B31</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tm0 OCA], [https://pdbe.org/3tm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tm0 RCSB], [https://www.ebi.ac.uk/pdbsum/3tm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tm0 ProSAT]</span></td></tr>
[[3tm0]] is a 1 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3h8p 3h8p]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TM0 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KKA3_ENTFL KKA3_ENTFL] Resistance to kanamycin and structurally-related aminoglycosides, including amikacin.


==See Also==
==See Also==
*[[Phosphotransferase|Phosphotransferase]]
*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:019433564</ref><references group="xtra"/>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
[[Category: Kanamycin kinase]]
[[Category: Large Structures]]
[[Category: Berghuis, A M.]]
[[Category: Berghuis AM]]
[[Category: Fong, D H.]]
[[Category: Fong DH]]
[[Category: Phosphorylation]]
[[Category: Protein kinase]]
[[Category: Transferase-antibiotic complex]]

Latest revision as of 16:33, 14 March 2024

Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Butirosin A ComplexCrystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Butirosin A Complex

Structural highlights

3tm0 is a 1 chain structure with sequence from Enterococcus faecalis. This structure supersedes the now removed PDB entry 3h8p. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KKA3_ENTFL Resistance to kanamycin and structurally-related aminoglycosides, including amikacin.

See Also

3tm0, resolution 2.10Å

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OCA
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