1xp0: Difference between revisions

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-[[Image:1xp0.png|left|200px]]
-{{STRUCTURE_1xp0|  PDB=1xp0  |  SCENE=  }}
+==Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil==
+<StructureSection load='1xp0' size='340' side='right'caption='[[1xp0]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
-===Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1xp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''cAMP-dependent Protein Kinase (PKA)''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_8 10.2210/rcsb_pdb/mom_2012_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XP0 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_15576036}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VDN:2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE'>VDN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xp0 OCA], [https://pdbe.org/1xp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xp0 RCSB], [https://www.ebi.ac.uk/pdbsum/1xp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xp0 ProSAT]</span></td></tr>
-[[1xp0]] is a 1 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XP0 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xp0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xp0 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Phosphodiesterase|Phosphodiesterase]]
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:015576036</ref><references group="xtra"/>
-[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
 [[Category: Homo sapiens]]
-[[Category: Artis, D R.]]
+[[Category: Large Structures]]
-[[Category: Bollag, G.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Card, G L.]]
+[[Category: Artis DR]]
-[[Category: England, B P.]]
+[[Category: Bollag G]]
-[[Category: Fong, D.]]
+[[Category: Card GL]]
-[[Category: Gillette, S.]]
+[[Category: England BP]]
-[[Category: Ibrahim, P N.]]
+[[Category: Fong D]]
-[[Category: Kim, S H.]]
+[[Category: Gillette S]]
-[[Category: Lee, B.]]
+[[Category: Ibrahim PN]]
-[[Category: Luu, C.]]
+[[Category: Kim S-H]]
-[[Category: Milburn, M V.]]
+[[Category: Lee B]]
-[[Category: Powell, B.]]
+[[Category: Luu C]]
-[[Category: Schlessinger, J.]]
+[[Category: Milburn MV]]
-[[Category: Suzuki, Y.]]
+[[Category: Powell B]]
-[[Category: Tabrizizad, M.]]
+[[Category: Schlessinger J]]
-[[Category: Zhang, K Y.J.]]
+[[Category: Suzuki Y]]
-[[Category: Hydrolase]]
+[[Category: Tabrizizad M]]
-[[Category: Levitra]]
+[[Category: Zhang KYJ]]
-[[Category: Pde]]
-[[Category: Pde5a]]
-[[Category: Phosphodiesterase]]
-[[Category: Vardenafil]]