2cos: Difference between revisions

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-[[Image:2cos.png|left|200px]]
-{{STRUCTURE_2cos|  PDB=2cos  |  SCENE=  }}
+==Solution structure of RSGI RUH-038, a UBA domain from Mouse LATS2 (Large Tumor Suppressor homolog 2)==
+<StructureSection load='2cos' size='340' side='right'caption='[[2cos]]' scene=''>
-===Solution structure of RSGI RUH-038, a UBA domain from Mouse LATS2 (Large Tumor Suppressor homolog 2)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2cos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COS FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cos OCA], [https://pdbe.org/2cos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cos RCSB], [https://www.ebi.ac.uk/pdbsum/2cos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cos ProSAT], [https://www.topsan.org/Proteins/RSGI/2cos TOPSAN]</span></td></tr>
-[[2cos]] is a 1 chain structure of [[Serine/threonine protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COS OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LATS2_MOUSE LATS2_MOUSE] Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).<ref>PMID:15343267</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/2cos_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cos ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-[[Category: Mus musculus]]
+== References ==
-[[Category: Non-specific serine/threonine protein kinase]]
+<references/>
-[[Category: Hayashi, F.]]
+__TOC__
-[[Category: Hirota, H.]]
+</StructureSection>
-[[Category: Onuki, H.]]
+[[Category: Large Structures]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
-[[Category: Yokoyama, S.]]
 [[Category: Mus musculus]]
-[[Category: National project on protein structural and functional analyse]]
+[[Category: Hayashi F]]
-[[Category: Nppsfa]]
+[[Category: Hirota H]]
-[[Category: Riken structural genomics/proteomics initiative]]
+[[Category: Onuki H]]
-[[Category: Rsgi]]
+[[Category: Yokoyama S]]
-[[Category: Structural genomic]]
-[[Category: Structure genomic]]
-[[Category: Transferase]]
-[[Category: Uba domain]]