1c03: Difference between revisions

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[[Image:1c03.png|left|200px]]


{{STRUCTURE_1c03|  PDB=1c03  |  SCENE=  }}
==CRYSTAL STRUCTURE OF YPD1P (TRICLINIC FORM)==
 
<StructureSection load='1c03' size='340' side='right'caption='[[1c03]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===CRYSTAL STRUCTURE OF YPD1P (TRICLINIC FORM)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1c03]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C03 FirstGlance]. <br>
{{ABSTRACT_PUBMED_10543964}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c03 OCA], [https://pdbe.org/1c03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c03 RCSB], [https://www.ebi.ac.uk/pdbsum/1c03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c03 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1c03]] is a 4 chain structure of [[Flock house virus B2 protein Suppression of RNA Silencing]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C03 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/YPD1_YEAST YPD1_YEAST] Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus.<ref>PMID:11073911</ref> <ref>PMID:9843501</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/1c03_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c03 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
*[[Flock house virus protein B2|Flock house virus protein B2]]
*[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]]
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:010543964</ref><references group="xtra"/>
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Lee, J. Y.]]
[[Category: Lee JY]]
[[Category: Lee, M. G.]]
[[Category: Lee MG]]
[[Category: Song, H. K.]]
[[Category: Song HK]]
[[Category: Suh, S. W.]]
[[Category: Suh SW]]
[[Category: Four helical bundle]]
[[Category: Signal transduction]]
[[Category: Signaling protein]]

Latest revision as of 09:40, 7 February 2024

CRYSTAL STRUCTURE OF YPD1P (TRICLINIC FORM)CRYSTAL STRUCTURE OF YPD1P (TRICLINIC FORM)

Structural highlights

1c03 is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

YPD1_YEAST Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Janiak-Spens F, Sparling DP, West AH. Novel role for an HPt domain in stabilizing the phosphorylated state of a response regulator domain. J Bacteriol. 2000 Dec;182(23):6673-8. PMID:11073911
  2. ↑ Li S, Ault A, Malone CL, Raitt D, Dean S, Johnston LH, Deschenes RJ, Fassler JS. The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p. EMBO J. 1998 Dec 1;17(23):6952-62. PMID:9843501 doi:http://dx.doi.org/10.1093/emboj/17.23.6952

1c03, resolution 2.30Å

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