1cws: Difference between revisions

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[[Image:1cws.png|left|200px]]


{{STRUCTURE_1cws|  PDB=1cws  |  SCENE=  }}
==HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE==
 
<StructureSection load='1cws' size='340' side='right'caption='[[1cws]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1cws]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CWS FirstGlance]. <br>
{{ABSTRACT_PUBMED_10543950}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cws OCA], [https://pdbe.org/1cws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cws RCSB], [https://www.ebi.ac.uk/pdbsum/1cws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cws ProSAT]</span></td></tr>
[[1cws]] is a 1 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWS OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cws_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cws ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
 
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:010543950</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chidester, C G.]]
[[Category: Large Structures]]
[[Category: Reynolds, R A.]]
[[Category: Chidester CG]]
[[Category: Watenpaugh, K D.]]
[[Category: Reynolds RA]]
[[Category: Cdc25]]
[[Category: Watenpaugh KD]]
[[Category: Cdc25b]]
[[Category: Cell cycle]]
[[Category: Cell cycle phosphatase]]
[[Category: Dual specificity protein phosphatase]]
[[Category: Hydrolase]]

Latest revision as of 18:44, 13 March 2024

HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATEHUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE

Structural highlights

1cws is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MPIP2_HUMAN Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Schmidt A, Durgan J, Magalhaes A, Hall A. Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis. EMBO J. 2007 Mar 21;26(6):1624-36. Epub 2007 Mar 1. PMID:17332740 doi:http://dx.doi.org/10.1038/sj.emboj.7601637

1cws, resolution 2.00Å

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OCA
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