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[[Image:2aaq.png|left|200px]]


{{STRUCTURE_2aaq|  PDB=2aaq  |  SCENE=  }}
==Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI==
 
<StructureSection load='2aaq' size='340' side='right'caption='[[2aaq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
===Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2aaq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AAQ FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=AUP:2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE'>AUP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[2aaq]] is a 1 chain structure of [[Glutathione Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAQ OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aaq OCA], [https://pdbe.org/2aaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aaq RCSB], [https://www.ebi.ac.uk/pdbsum/2aaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aaq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GSHR_HUMAN GSHR_HUMAN] Maintains high levels of reduced glutathione in the cytosol.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aa/2aaq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aaq ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Glutathione Reductase|Glutathione Reductase]]
*[[Glutathione Reductase|Glutathione Reductase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016493712</ref><references group="xtra"/>
[[Category: Glutathione-disulfide reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Becker, K.]]
[[Category: Large Structures]]
[[Category: Davioud-Charvet, E.]]
[[Category: Becker K]]
[[Category: Fritz-Wolf, K.]]
[[Category: Davioud-Charvet E]]
[[Category: Herold-Mende, C.]]
[[Category: Fritz-Wolf K]]
[[Category: Reau, R.]]
[[Category: Herold-Mende C]]
[[Category: Toth, K.]]
[[Category: Reau R]]
[[Category: Urig, S.]]
[[Category: Toth K]]
[[Category: Antioxidative system]]
[[Category: Urig S]]
[[Category: Disulfide reductase]]
[[Category: Glutathione reduction]]
[[Category: Gold-coordination]]
[[Category: Homodimer]]
[[Category: Oxidoreductase]]
[[Category: Protein gold complex]]

Latest revision as of 10:48, 30 October 2024

Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPICrystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI

Structural highlights

2aaq is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:, , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GSHR_HUMAN Maintains high levels of reduced glutathione in the cytosol.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2aaq, resolution 2.60Å

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