2kim: Difference between revisions

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[[Image:2kim.png|left|200px]]


{{STRUCTURE_2kim|  PDB=2kim  |  SCENE=  }}
==1.7-mm microcryoprobe solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.==
 
<StructureSection load='2kim' size='340' side='right'caption='[[2kim]]' scene=''>
===1.7-mm microcryoprobe solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2kim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_AQ3810 Vibrio parahaemolyticus AQ3810]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIM FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kim OCA], [https://pdbe.org/2kim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kim RCSB], [https://www.ebi.ac.uk/pdbsum/2kim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kim ProSAT], [https://www.topsan.org/Proteins/NESGC/2kim TOPSAN]</span></td></tr>
[[2kim]] is a 1 chain structure of [[DNA methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_aq3810 Vibrio parahaemolyticus aq3810]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIM OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATL_VIBPQ ATL_VIBPQ] Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins (By similarity).[UniProtKB:P0AFP2]<ref>PMID:20212037</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/2kim_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kim ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA methyltransferase|DNA methyltransferase]]
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
[[Category: Vibrio parahaemolyticus aq3810]]
== References ==
[[Category: Acton, T B.]]
<references/>
[[Category: Aramini, J M.]]
__TOC__
[[Category: Belote, R L.]]
</StructureSection>
[[Category: Ciccosanti, C T.]]
[[Category: Large Structures]]
[[Category: Everett, J K.]]
[[Category: Vibrio parahaemolyticus AQ3810]]
[[Category: Jiang, M.]]
[[Category: Acton TB]]
[[Category: Montelione, G T.]]
[[Category: Aramini JM]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Belote RL]]
[[Category: Nair, R.]]
[[Category: Ciccosanti CT]]
[[Category: Rost, B.]]
[[Category: Everett JK]]
[[Category: Swapna, G V.T]]
[[Category: Jiang M]]
[[Category: Xiao, R.]]
[[Category: Montelione GT]]
[[Category: Dna base repair]]
[[Category: Nair R]]
[[Category: Methods development]]
[[Category: Rost B]]
[[Category: Methyltransferase]]
[[Category: Swapna GVT]]
[[Category: Nesg]]
[[Category: Xiao R]]
[[Category: Northeast structural genomics consortium]]
[[Category: O6 methylguanine methyltransferase]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Solution nmr structure]]
[[Category: Structural genomic]]
[[Category: Transferase]]

Latest revision as of 09:46, 1 May 2024

1.7-mm microcryoprobe solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.1.7-mm microcryoprobe solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.

Structural highlights

2kim is a 1 chain structure with sequence from Vibrio parahaemolyticus AQ3810. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

ATL_VIBPQ Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins (By similarity).[UniProtKB:P0AFP2][1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Aramini JM, Tubbs JL, Kanugula S, Rossi P, Ertekin A, Maglaqui M, Hamilton K, Ciccosanti CT, Jiang M, Xiao R, Soong TT, Rost B, Acton TB, Everett JK, Pegg AE, Tainer JA, Montelione GT. Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein. J Biol Chem. 2010 Apr 30;285(18):13736-41. Epub 2010 Mar 8. PMID:20212037 doi:10.1074/jbc.M109.093591
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