3lrv: Difference between revisions

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-[[Image:3lrv.png|left|200px]]
-{{STRUCTURE_3lrv|  PDB=3lrv  |  SCENE=  }}
+==The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function.==
+<StructureSection load='3lrv' size='340' side='right'caption='[[3lrv]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-===The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function.===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3lrv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LRV FirstGlance]. <br>
-{{ABSTRACT_PUBMED_20462492}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrv OCA], [https://pdbe.org/3lrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lrv RCSB], [https://www.ebi.ac.uk/pdbsum/3lrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrv ProSAT]</span></td></tr>
-[[3lrv]] is a 1 chain structure of [[Pre-mRNA-splicing factor]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRV OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRP19_YEAST PRP19_YEAST] Involved in pre-mRNA splicing. Acts a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Involved in DNA repair.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/3lrv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lrv ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
+*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
-*[[Prp19|Prp19]]
+__TOC__
+</StructureSection>
-==Reference==
+[[Category: Large Structures]]
-<ref group="xtra">PMID:020462492</ref><references group="xtra"/>
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Chazin, W J.]]
+[[Category: Chazin WJ]]
-[[Category: Kooi, C W.Vander.]]
+[[Category: Vander Kooi CW]]
-[[Category: Dna damage]]
-[[Category: Dna repair]]
-[[Category: E3 ubiquitin ligase]]
-[[Category: Mrna processing]]
-[[Category: Mrna splicing]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Prp19]]
-[[Category: Spliceosome]]
-[[Category: Splicing]]
-[[Category: Wd repeat]]
-[[Category: Wd40]]