3a1a: Difference between revisions

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[[Image:3a1a.png|left|200px]]


{{STRUCTURE_3a1a|  PDB=3a1a  |  SCENE=  }}
==Crystal Structure of the DNMT3A ADD domain==
 
<StructureSection load='3a1a' size='340' side='right'caption='[[3a1a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal Structure of the DNMT3A ADD domain===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3a1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1A FirstGlance]. <br>
{{ABSTRACT_PUBMED_19834512}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1a OCA], [https://pdbe.org/3a1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1a RCSB], [https://www.ebi.ac.uk/pdbsum/3a1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1a ProSAT]</span></td></tr>
[[3a1a]] is a 1 chain structure of [[DNA methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1A OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNM3A_HUMAN DNM3A_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).<ref>PMID:16357870</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/3a1a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a1a ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA methyltransferase|DNA methyltransferase]]
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019834512</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arita, K.]]
[[Category: Large Structures]]
[[Category: Ariyoshi, M.]]
[[Category: Arita K]]
[[Category: Otani, J.]]
[[Category: Ariyoshi M]]
[[Category: Shirakawa, M.]]
[[Category: Otani J]]
[[Category: Alternative promoter usage]]
[[Category: Shirakawa M]]
[[Category: Dna-binding]]
[[Category: Metal-binding]]
[[Category: Methyltransferase]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Transferase]]
[[Category: Zinc-finger]]

Latest revision as of 16:59, 13 March 2024

Crystal Structure of the DNMT3A ADD domainCrystal Structure of the DNMT3A ADD domain

Structural highlights

3a1a is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DNM3A_HUMAN Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y, Fuks F. The Polycomb group protein EZH2 directly controls DNA methylation. Nature. 2006 Feb 16;439(7078):871-4. Epub 2005 Dec 14. PMID:16357870 doi:10.1038/nature04431

3a1a, resolution 2.30Å

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