3ixd: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:3ixd.png|left|200px]]
-{{STRUCTURE_3ixd|  PDB=3ixd  |  SCENE=  }}
+==X-ray crystal structure of the extended-spectrum AmpC V298E mutant beta-lactamase at 2.64 Angstrom resolution==
+<StructureSection load='3ixd' size='340' side='right'caption='[[3ixd]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
-===X-ray crystal structure of the extended-spectrum AmpC V298E mutant beta-lactamase at 2.64 Angstrom resolution===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ixd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IXD FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19913034}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ixd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixd OCA], [https://pdbe.org/3ixd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ixd RCSB], [https://www.ebi.ac.uk/pdbsum/3ixd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixd ProSAT]</span></td></tr>
-[[3ixd]] is a 2 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXD OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixd_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ixd ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Beta-lactamase|Beta-lactamase]]
+*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:019913034</ref><references group="xtra"/>
+[[Category: Escherichia coli K-12]]
-[[Category: Beta-lactamase]]
+[[Category: Large Structures]]
-[[Category: Escherichia coli]]
+[[Category: Shoichet BK]]
-[[Category: Shoichet, B K.]]
+[[Category: Thomas VL]]
-[[Category: Thomas, V L.]]
-[[Category: Antibiotic resistance]]
-[[Category: Beta-lactamase]]
-[[Category: Cephalosporinase]]
-[[Category: Extended-spectrum antibiotic resistance]]
-[[Category: Hydrolase]]
-[[Category: Serine hydrolase]]