1m2z: Difference between revisions

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-[[Image:1m2z.png|left|200px]]
-{{STRUCTURE_1m2z|  PDB=1m2z  |  SCENE=  }}
+==Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif==
+<StructureSection load='1m2z' size='340' side='right'caption='[[1m2z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-===Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1m2z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2Z FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12151000}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2z OCA], [https://pdbe.org/1m2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2z RCSB], [https://www.ebi.ac.uk/pdbsum/1m2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2z ProSAT]</span></td></tr>
-[[1m2z]] is a 4 chain structure of [[Glucocorticoid receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2Z OCA].
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m2z_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m2z ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Glucocorticoid receptor|Glucocorticoid receptor]]
+*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
-==Reference==
+== References ==
-<ref group="xtra">PMID:012151000</ref><ref group="xtra">PMID:019756040</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Apolito, C J.]]
+[[Category: Large Structures]]
-[[Category: Bledsoe, R B.]]
+[[Category: Apolito CJ]]
-[[Category: Consler, T G.]]
+[[Category: Bledsoe RB]]
-[[Category: Delves, C J.]]
+[[Category: Consler TG]]
-[[Category: Lambert, M H.]]
+[[Category: Delves CJ]]
-[[Category: Mckee, D D.]]
+[[Category: Lambert MH]]
-[[Category: Montana, V G.]]
+[[Category: Mckee DD]]
-[[Category: Moore, J T.]]
+[[Category: Montana VG]]
-[[Category: Parks, D J.]]
+[[Category: Moore JT]]
-[[Category: Pearce, K H.]]
+[[Category: Parks DJ]]
-[[Category: Stanley, T B.]]
+[[Category: Pearce KH]]
-[[Category: Stewart, E L.]]
+[[Category: Stanley TB]]
-[[Category: Willson, T M.]]
+[[Category: Stewart EL]]
-[[Category: Xu, H E.]]
+[[Category: Willson TM]]
-[[Category: Charge clamp]]
+[[Category: Xu HE]]
-[[Category: Coactivator]]
-[[Category: Dexamethasone]]
-[[Category: Dimer interface]]
-[[Category: Glucocorticoid receptor]]
-[[Category: Hormone binding pocket]]
-[[Category: Hormone-hormone activator complex]]
-[[Category: Tif2]]