2kfn: Difference between revisions

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-[[Image:2kfn.png|left|200px]]
-{{STRUCTURE_2kfn|  PDB=2kfn  |  SCENE=  }}
+==KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND MANGANESE==
+<StructureSection load='2kfn' size='340' side='right'caption='[[2kfn]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-===KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND MANGANESE===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2kfn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KFN FirstGlance]. <br>
-{{ABSTRACT_PUBMED_9888810}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=US1:2-DEOXY-3-THIOURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>US1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kfn OCA], [https://pdbe.org/2kfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kfn RCSB], [https://www.ebi.ac.uk/pdbsum/2kfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kfn ProSAT]</span></td></tr>
-[[2kfn]] is a 2 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFN OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DPO1_ECOLI DPO1_ECOLI] In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/2kfn_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kfn ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[DNA polymerase|DNA polymerase]]
+*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:009888810</ref><references group="xtra"/>
-[[Category: DNA-directed DNA polymerase]]
 [[Category: Escherichia coli]]
-[[Category: Brautigam, C A.]]
+[[Category: Large Structures]]
-[[Category: Piccirilli, J A.]]
+[[Category: Brautigam CA]]
-[[Category: Steitz, T A.]]
+[[Category: Piccirilli JA]]
-[[Category: Sun, S.]]
+[[Category: Steitz TA]]
-[[Category: Exonuclease]]
+[[Category: Sun S]]
-[[Category: Transferase]]
-[[Category: Transferase-dna complex]]