1ki4: Difference between revisions

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[[Image:1ki4.png|left|200px]]


{{STRUCTURE_1ki4|  PDB=1ki4  |  SCENE=  }}
==CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINE==
 
<StructureSection load='1ki4' size='340' side='right'caption='[[1ki4]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ki4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KI4 FirstGlance]. <br>
{{ABSTRACT_PUBMED_9715911}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTD:5-BROMOTHIENYLDEOXYURIDINE'>BTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ki4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ki4 OCA], [https://pdbe.org/1ki4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ki4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ki4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ki4 ProSAT]</span></td></tr>
[[1ki4]] is a 2 chain structure of [[Thymidine kinase]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI4 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1ki4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ki4 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Thymidine kinase|Thymidine kinase]]
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:009715911</ref><references group="xtra"/>
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Thymidine kinase]]
[[Category: Large Structures]]
[[Category: Viruses]]
[[Category: Bennett MS]]
[[Category: Bennett, M S.]]
[[Category: Champness JN]]
[[Category: Champness, J N.]]
[[Category: Sanderson MR]]
[[Category: Sanderson, M R.]]
[[Category: Summers WC]]
[[Category: Summers, W C.]]
[[Category: Visse R]]
[[Category: Visse, R.]]
[[Category: Wien F]]
[[Category: Wien, F.]]
[[Category: 5-bromothienyldeoxyuridine]]
[[Category: Alphaherpesvirinae]]
[[Category: Ds-dna enveloped viruse]]
[[Category: Herpesviridae]]
[[Category: Phosphotransferase]]
[[Category: Substrate analog]]
[[Category: Thymidine kinase]]
[[Category: Viridae]]

Latest revision as of 10:25, 14 February 2024

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINECRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINE

Structural highlights

1ki4 is a 2 chain structure with sequence from Human alphaherpesvirus 1 strain 17. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.34Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KITH_HHV11 In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ki4, resolution 2.34Å

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