1ah4: Difference between revisions

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-[[Image:1ah4.png|left|200px]]
-{{STRUCTURE_1ah4|  PDB=1ah4  |  SCENE=  }}
+==PIG ALDOSE REDUCTASE, HOLO FORM==
+<StructureSection load='1ah4' size='340' side='right'caption='[[1ah4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===PIG ALDOSE REDUCTASE, HOLO FORM===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ah4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AH4 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_9195881}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYA:N-ACETYLALANINE'>AYA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ah4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ah4 OCA], [https://pdbe.org/1ah4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ah4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ah4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ah4 ProSAT]</span></td></tr>
-[[1ah4]] is a 1 chain structure of [[Aldose Reductase]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH4 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ALDR_PIG ALDR_PIG] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ah4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ah4 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Aldose Reductase|Aldose Reductase]]
+*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
-==Reference==
+__TOC__
-<ref group="xtra">PMID:009195881</ref><references group="xtra"/>
+</StructureSection>
-[[Category: Aldehyde reductase]]
+[[Category: Large Structures]]
 [[Category: Sus scrofa]]
-[[Category: Moras, D.]]
+[[Category: Moras D]]
-[[Category: Podjarny, A.]]
+[[Category: Podjarny A]]
-[[Category: Aldose reductase]]
-[[Category: Diabetes]]
-[[Category: Inhibition]]
-[[Category: Oxidoreductase]]