1c24: Difference between revisions

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-[[Image:1c24.png|left|200px]]
-{{STRUCTURE_1c24|  PDB=1c24  |  SCENE=  }}
+==E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHINATE COMPLEX==
+<StructureSection load='1c24' size='340' side='right'caption='[[1c24]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-===E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHINATE COMPLEX===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1c24]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C24 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10555963}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MPJ:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHINIC+ACID'>MPJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c24 OCA], [https://pdbe.org/1c24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c24 RCSB], [https://www.ebi.ac.uk/pdbsum/1c24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c24 ProSAT]</span></td></tr>
-[[1c24]] is a 1 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C24 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MAP1_ECOLI MAP1_ECOLI] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:20521764</ref> <ref>PMID:3027045</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/1c24_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c24 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Aminopeptidase|Aminopeptidase]]
+*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:010555963</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Escherichia coli]]
-[[Category: Methionyl aminopeptidase]]
+[[Category: Large Structures]]
-[[Category: Honek, J F.]]
+[[Category: Honek JF]]
-[[Category: Lowther, W T.]]
+[[Category: Lowther WT]]
-[[Category: Matthews, B W.]]
+[[Category: Matthews BW]]
-[[Category: Sampson, P B.]]
+[[Category: Sampson PB]]
-[[Category: Zhang, Y.]]
+[[Category: Zhang Y]]
-[[Category: Hydrolase]]
-[[Category: Product complex]]