1kph: Difference between revisions

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[[Image:1kph.png|left|200px]]


{{STRUCTURE_1kph|  PDB=1kph  |  SCENE=  }}
==Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and DDDMAB==
 
<StructureSection load='1kph' size='340' side='right'caption='[[1kph]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and DDDMAB===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1kph]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KPH FirstGlance]. <br>
{{ABSTRACT_PUBMED_11756461}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10A:DIDECYL-DIMETHYL-AMMONIUM'>10A</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kph OCA], [https://pdbe.org/1kph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kph RCSB], [https://www.ebi.ac.uk/pdbsum/1kph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kph ProSAT], [https://www.topsan.org/Proteins/TBSGC/1kph TOPSAN]</span></td></tr>
[[1kph]] is a 4 chain structure of [[Fatty acid synthase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPH OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CMAS1_MYCTU CMAS1_MYCTU] Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.<ref>PMID:7592990</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/1kph_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kph ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Fatty acid synthase|Fatty acid synthase]]
*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011756461</ref><ref group="xtra">PMID:012462144</ref><references group="xtra"/>
__TOC__
[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Glickman, M S.]]
[[Category: Glickman MS]]
[[Category: Huang, C C.]]
[[Category: Huang C-C]]
[[Category: Jacobs, W R.]]
[[Category: Jacobs Jr WR]]
[[Category: Sacchettini, J C.]]
[[Category: Sacchettini JC]]
[[Category: Smith, C V.]]
[[Category: Smith CV]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Mixed alpha beta fold]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Transferase]]

Latest revision as of 10:26, 14 February 2024

Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and DDDMABCrystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and DDDMAB

Structural highlights

1kph is a 4 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

CMAS1_MYCTU Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ George KM, Yuan Y, Sherman DR, Barry CE 3rd. The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2. J Biol Chem. 1995 Nov 10;270(45):27292-8. PMID:7592990

1kph, resolution 2.00Å

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