2qth: Difference between revisions

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[[Image:2qth.png|left|200px]]


{{STRUCTURE_2qth|  PDB=2qth  |  SCENE=  }}
==Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDP==
 
<StructureSection load='2qth' size='340' side='right'caption='[[2qth]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2qth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QTH FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[2qth]] is a 1 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTH OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qth OCA], [https://pdbe.org/2qth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qth RCSB], [https://www.ebi.ac.uk/pdbsum/2qth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qth ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HFLX_SACS2 HFLX_SACS2] GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP.[HAMAP-Rule:MF_00900]<ref>PMID:19787775</ref> <ref>PMID:21478358</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/2qth_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qth ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[GTP-binding protein|GTP-binding protein]]
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
[[Category: Sulfolobus solfataricus p2]]
== References ==
[[Category: Brouns, S J.]]
<references/>
[[Category: Fu, S.]]
__TOC__
[[Category: Oost, J Van der.]]
</StructureSection>
[[Category: Rao, Z.]]
[[Category: Large Structures]]
[[Category: Sun, L.]]
[[Category: Saccharolobus solfataricus P2]]
[[Category: Wu, H.]]
[[Category: Brouns SJ]]
[[Category: Beta-alpha-barrel]]
[[Category: Fu S]]
[[Category: Gtp-binding]]
[[Category: Rao Z]]
[[Category: Nucleotide binding protein]]
[[Category: Sun L]]
[[Category: Nucleotide-binding]]
[[Category: Van der Oost J]]
[[Category: Wu H]]

Latest revision as of 12:17, 21 February 2024

Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDPCrystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDP

Structural highlights

2qth is a 1 chain structure with sequence from Saccharolobus solfataricus P2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HFLX_SACS2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP.[HAMAP-Rule:MF_00900][1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Wu H, Sun L, Blombach F, Brouns SJ, Snijders AP, Lorenzen K, van den Heuvel RH, Heck AJ, Fu S, Li X, Zhang XC, Rao Z, van der Oost J. Structure of the ribosome associating GTPase HflX. Proteins. 2010 Feb 15;78(3):705-13. doi: 10.1002/prot.22599. PMID:19787775 doi:http://dx.doi.org/10.1002/prot.22599
  2. ↑ Blombach F, Launay H, Zorraquino V, Swarts DC, Cabrita LD, Benelli D, Christodoulou J, Londei P, van der Oost J. An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states. J Bacteriol. 2011 Jun;193(11):2861-7. doi: 10.1128/JB.01552-10. Epub 2011 Apr 8. PMID:21478358 doi:http://dx.doi.org/10.1128/JB.01552-10

2qth, resolution 2.00Å

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