3qyo: Difference between revisions

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-[[Image:3qyo.png|left|200px]]
-{{STRUCTURE_3qyo|  PDB=3qyo  |  SCENE=  }}
+==Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate==
+<StructureSection load='3qyo' size='340' side='right'caption='[[3qyo]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
-===Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3qyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QYO FirstGlance]. <br>
-{{ABSTRACT_PUBMED_22246400}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=Q24:QUINAZOLINE-2,4-DIAMINE'>Q24</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyo OCA], [https://pdbe.org/3qyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qyo RCSB], [https://www.ebi.ac.uk/pdbsum/3qyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyo ProSAT]</span></td></tr>
-[[3qyo]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYO OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 ==See Also==
-*[[Dihydrofolate reductase|Dihydrofolate reductase]]
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:022246400</ref><references group="xtra"/>
+[[Category: Escherichia coli K-12]]
-[[Category: Dihydrofolate reductase]]
+[[Category: Large Structures]]
-[[Category: Escherichia coli k-12]]
+[[Category: Carroll MJ]]
-[[Category: Carroll, M J.]]
+[[Category: Collins EJ]]
-[[Category: Collins, E J.]]
+[[Category: Gromova AV]]
-[[Category: Gromova, A V.]]
+[[Category: Lee AL]]
-[[Category: Lee, A L.]]
+[[Category: Mauldin RV]]
-[[Category: Mauldin, R V.]]
+[[Category: Singleton SF]]
-[[Category: Singleton, S F.]]
-[[Category: Oxidoreductase]]
-[[Category: Reductase]]
-[[Category: Rossman fold]]