2ouc: Difference between revisions

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[[Image:2ouc.png|left|200px]]


{{STRUCTURE_2ouc|  PDB=2ouc  |  SCENE=  }}
==Crystal structure of the MAP kinase binding domain of MKP5==
 
<StructureSection load='2ouc' size='340' side='right'caption='[[2ouc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===Crystal structure of the MAP kinase binding domain of MKP5===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ouc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OUC FirstGlance]. <br>
{{ABSTRACT_PUBMED_17400920}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ouc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ouc OCA], [https://pdbe.org/2ouc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ouc RCSB], [https://www.ebi.ac.uk/pdbsum/2ouc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ouc ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2ouc]] is a 2 chain structure of [[MAP kinase phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUC OCA].  
== Function ==
[https://www.uniprot.org/uniprot/DUS10_HUMAN DUS10_HUMAN] Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.<ref>PMID:22375048</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/2ouc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ouc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[MAP kinase phosphatase|MAP kinase phosphatase]]
*[[MAP kinase phosphatase|MAP kinase phosphatase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:017400920</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Tao, X.]]
[[Category: Large Structures]]
[[Category: Tong, L.]]
[[Category: Tao X]]
[[Category: Hydrolase]]
[[Category: Tong L]]
[[Category: Rhodanese fold]]

Latest revision as of 12:06, 21 February 2024

Crystal structure of the MAP kinase binding domain of MKP5Crystal structure of the MAP kinase binding domain of MKP5

Structural highlights

2ouc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DUS10_HUMAN Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zhang YY, Wu JW, Wang ZX. A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38alpha with the MAPK Binding Domain of the Phosphatase MKP5. Sci Signal. 2011 Dec 20;4(204):ra88. PMID:22375048 doi:10.1126/scisignal.2002241

2ouc, resolution 2.20Å

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OCA
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