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[[Image:1bo6.gif|left|200px]]<br /><applet load="1bo6" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1bo6, resolution 2.10&Aring;" />
'''ESTROGEN SULFOTRANSFERASE WITH INACTIVE COFACTOR PAP AND VANADATE'''<br />


==Overview==
==ESTROGEN SULFOTRANSFERASE WITH INACTIVE COFACTOR PAP AND VANADATE==
The structure of estrogen sulphotransferase has been solved in the presence of inactive cofactor PAP and substrate 17 beta-estradiol. This structure reveals structural similarities between cytosolic sulphotransferases and nucleotide kinases.
<StructureSection load='1bo6' size='340' side='right'caption='[[1bo6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bo6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BO6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bo6 OCA], [https://pdbe.org/1bo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bo6 RCSB], [https://www.ebi.ac.uk/pdbsum/1bo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bo6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ST1E1_MOUSE ST1E1_MOUSE] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/1bo6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bo6 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1BO6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=VO4:'>VO4</scene> and <scene name='pdbligand=A3P:'>A3P</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Estrone_sulfotransferase Estrone sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.4 2.8.2.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO6 OCA].
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of estrogen sulphotransferase., Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC, Nat Struct Biol. 1997 Nov;4(11):904-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9360604 9360604]
[[Category: Large Structures]]
[[Category: Estrone sulfotransferase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Kakuta Y]]
[[Category: Kakuta, Y.]]
[[Category: Negishi M]]
[[Category: Negishi, M.]]
[[Category: Pedersen LC]]
[[Category: Pedersen, L C.]]
[[Category: A3P]]
[[Category: VO4]]
[[Category: pap]]
[[Category: sulfonation]]
[[Category: sulfotransferase]]
[[Category: transferase]]
[[Category: vanadate]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:57:17 2008''

Latest revision as of 09:38, 7 February 2024

ESTROGEN SULFOTRANSFERASE WITH INACTIVE COFACTOR PAP AND VANADATEESTROGEN SULFOTRANSFERASE WITH INACTIVE COFACTOR PAP AND VANADATE

Structural highlights

1bo6 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ST1E1_MOUSE Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1bo6, resolution 2.10Å

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