1f28: Difference between revisions

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[[Image:1f28.png|left|200px]]


{{STRUCTURE_1f28|  PDB=1f28  |  SCENE=  }}
==CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89==
 
<StructureSection load='1f28' size='340' side='right'caption='[[1f28]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1f28]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F28 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11358692}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F89:S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC+ACID'>F89</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f28 OCA], [https://pdbe.org/1f28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f28 RCSB], [https://www.ebi.ac.uk/pdbsum/1f28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f28 ProSAT]</span></td></tr>
[[1f28]] is a 4 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F28 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_PNECA TYSY_PNECA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/1f28_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f28 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011358692</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Pneumocystis carinii]]
[[Category: Pneumocystis carinii]]
[[Category: Thymidylate synthase]]
[[Category: Anderson AC]]
[[Category: Anderson, A C.]]
[[Category: O'Neil RH]]
[[Category: Neil, R H.O.]]
[[Category: Stroud RM]]
[[Category: Stroud, R M.]]
[[Category: Surti TS]]
[[Category: Surti, T S.]]
[[Category: Beta-sheet]]
[[Category: Protein-inhibitor complex]]
[[Category: Transferase]]

Latest revision as of 13:09, 20 March 2024

CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89

Structural highlights

1f28 is a 4 chain structure with sequence from Pneumocystis carinii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYSY_PNECA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1f28, resolution 1.90Å

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OCA
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